Research Article
Research Progress and Controversy on the Relationship Between Iodine Excess and Thyroid Cancer Occurrence
Zhou Feng,
Liu Na,
Yang Guiran*
Issue:
Volume 12, Issue 1, February 2024
Pages:
1-7
Received:
11 December 2023
Accepted:
8 January 2024
Published:
11 January 2024
Abstract: Thyroid cancer is the most common thyroid malignant tumor, and its incidence rate is on the rise in most countries. Iodine is an essential trace element for the synthesis of thyroid hormones in the human body. Long term excessive iodine can induce thyroid diseases such as hyperthyroidism and thyroid nodules, but its relationship with the occurrence of thyroid cancer is uncertain. There may be regional differences and some confusing or interfering factors, due to the influence of iodine intake and dietary habits on the final iodine nutritional status of the human body, and the influence of water iodine content on the iodine nutritional status of the human body. In recent years, researchers have revealed the relationship between iodine excess and thyroid cancer through ecological studies of regional water iodine distribution, dietary iodine and thyroid cancer, but the results are controversial. In the epidemiological studies on the correlation between urinary iodine concentration and thyroid cancer in residents, there is no conclusion on the correlation between urinary iodine concentration and iodine level of thyroid cancer patients and whether MUI can truly reflect the iodine nutrition level of thyroid cancer patients. This article reviews the research progress and controversies on the relationship between iodine excess and thyroid cancer, and comments on the possible reasons for the controversies, providing reference for future research.
Abstract: Thyroid cancer is the most common thyroid malignant tumor, and its incidence rate is on the rise in most countries. Iodine is an essential trace element for the synthesis of thyroid hormones in the human body. Long term excessive iodine can induce thyroid diseases such as hyperthyroidism and thyroid nodules, but its relationship with the occurrence...
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Review Article
Sepsis, Antimicrobial Resistance, and Alternative Therapies
Negeri Debela*,
Solome Nekahiwot
Issue:
Volume 12, Issue 1, February 2024
Pages:
8-18
Received:
2 February 2024
Accepted:
22 February 2024
Published:
7 March 2024
Abstract: Sepsis, a life-threatening condition caused by the body's excessive response to an infection, has emerged as a global health menace. Around 20% of all global deaths are attributable to sepsis. Conversely, the presence of antimicrobial resistance (AMR) poses a significant peril to the health system. AMR constitutes an escalating pandemic that we must not disregard, as the absence of effective antibiotics would compromise the treatment of even commonplace bacterial infections. Therefore, the increasing prevalence of AMR further adds complexity to the management and outcomes of individuals with sepsis. AMR plays a contributory role in aggravating the consequences of sepsis, ranging from prolonged hospitalization to mortality. The World Health Organization (WHO) has prioritized AMR as a major concern necessitating immediate action to prevent dire consequences in the future. Though, One Health approach, infection prevention, rational use of antibiotics, strengthening surveillance systems, as well as research and development, are crucial strategies in combating antimicrobial resistance, alternative therapies, such as phage therapy and immunotherapeutics, are being explored for the management of AMR infections. Advances in these therapies show promise in addressing the challenges posed by antibiotic resistance in treating sepsis. In this critical assessment, we succinctly delineate the existing challenges of AMR in managing sepsis cases, and we provide an overview of the advancements in treating sepsis through alternative therapeutic modalities.
Abstract: Sepsis, a life-threatening condition caused by the body's excessive response to an infection, has emerged as a global health menace. Around 20% of all global deaths are attributable to sepsis. Conversely, the presence of antimicrobial resistance (AMR) poses a significant peril to the health system. AMR constitutes an escalating pandemic that we mus...
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